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The plasma which occurs is minor, but over time and thousands of contact closures does contribute to eroding and wearing away of the contact surfaces...this is certainly tougher duty for the contact than if it did not have to control the current, but that is the point of the whole thing, so when contacts are sized appropriately for the expected Load Current during circuit engineering, the they will typically last for a long service-life

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Among patients who are smokers, who have more complex cancers that have hundreds, sometimes thousands of mutations, dont have a driver mutation that we can give a pill for, which is only a tiny percentage of lifelong smokers